Receptor tyrosine-protein kinase erbB-2 (ERBB2). Protein tyrosine kinase that is part of several cell surface receptor complexes. In the nucleus it is involved in transcriptional regulation. Enhances protein synthesis and cell growth.
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The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present. The last three rows describe the position of potential epitopes, as well as phosphorylation and glycosylation sites.