Description

Receptor tyrosine-protein kinase erbB-2 (ERBB2). Protein tyrosine kinase that is part of several cell surface receptor complexes. In the nucleus it is involved in transcriptional regulation. Enhances protein synthesis and cell growth.


Clinical trials

NCT03740256 - Bladder Cancer, Breast Cancer, Colorectal Cancer, Esophagus Cancer, Head and Neck Squamous Cell Carcinoma, Lung Cancer, Pancreatic Adenocarcinoma
NCT03696030 - Breast Cancer
NCT02547961 - Breast Cancer
NCT04511871 - Breast Cancer, Ovarian Cancer, Sarcoma
NCT02713984 - Breast Cancer, Colorectal Cancer, Lung Cancer, Ovarian Cancer, Pancreatic Adenocarcinoma
NCT01109095 - Glioblastoma Multiforme
NCT03267173 - Pancreatic Cancer
NCT00902044 - Sarcoma


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene ERBB2.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present. The last three rows describe the position of potential epitopes, as well as phosphorylation and glycosylation sites.